The subject of Metabolic Diseases is vast and complex. Attempt has been made to cover metabolic diseases in a systematic and simplified manner. The disorders have been classified into disorders of homeostasis, acid base imbalance, metabolism of biomolecules and porphyrias. A detailed module on Diabetes Mellitus has been added with an aim to cover this disorder of carbohydrate metabolism in depth because it is also a lifestyle disorder and an extremely common ailment in today’s medical practice.

• 1. What is Metabolic Disease?   FREE 18 min

  The module gives a description of metabolic diseases to the learner, throwing light on the myriad disorders of metabolism of different elements that lay the foundation of life in human body. Disorders of metabolism of water, electrolytes and biomolecules along with acid base imbalance and porphyrias have been briefly touched upon in this module.

• 2. Impaired Homeostasis: Water 41 min

  This module deals with the renal handling of water and the consequences of a fault therein. The aetiology, pathogenesis, clinical features, investigations and the management strategies for conditions arising due to an impaired water homeostasis have been talked about in depth in this module.

• 3. Impaired Homeostasis: Sodium 45 min

  This module elaborates upon the physiology of sodium metabolism along with the consequences of an impaired homeostasis of sodium. The disorders of sodium metabolism have been thoroughly discussed giving emphasis upon their aetiology, pathogenesis, clinical presentation, investigations and management protocol.

• 4. Impaired Homeostasis: Potassium 45 min

  This module elaborates upon the physiology of potassium metabolism along with the consequences of an impaired homeostasis of potassium. The disorders of potassium metabolism have been thoroughly discussed giving emphasis upon their aetiology, pathogenesis, clinical presentation, investigations and management protocol.

• 5. Impaired Homeostasis: Calcium 37 min

  Calcium is the most important element in the body. The regulation and metabolism of this element has been discussed in detail in this module elaborating the disorders that result from an imbalance in the metabolism of ionized calcium along with the aetiology, pathogenesis, clinical features, investigations and management of each.

• 6. Impaired Homeostasis: Magnesium 25 min

  This module deals with the metabolism of Magnesium in its ionic form. It talks about the physiology of Magnesium metabolism followed by the conditions which result when homeostasis of Magnesium is disturbed. The module also gives excerpts from reports of latest researches conducted in the field of Magnesium Metabolism.

• 7. Impaired Homeostasis: Phosphate 32 min

  Phosphates are essential for a number of reactions in the body apart from being a constituent of the skeleton. This element is much neglected though. The module covers in depth, the disorders which result when the metabolism of Phosphates is impaired.

• 8. Acid Base Imbalance 47 min

  This module deals with four conditions namely Respiratory Acidosis, Respiratory Alkalosis, Metabolic Acidosis and Metabolic Alkalosis in great depth, contrasted with the concept of maintenance of neutrality of blood.

• 9. Porphyrias 36 min

  Porphyrias are inherited disorders caused by impaired production of heme from porphyrin. This module elaborates upon the different types of porphyrias encountered in medical practice.

• 10. Disorders of Amino Acid Metabolism 42 min

  Amino acids are biomolecules obtained from the digestion of Proteins. Impaired metabolism of these biomolecules result in a variety of disorders, which have been covered thoroughly in this module.

• 11. Disorders of Lipid Metabolism 19 min

  This module covers the metabolism of biologically important lipids followed by an in depth discussion on the conditions produced by a disordered metabolism of lipids. The conditions have been explained thoroughly elaborating the aetiology, pathogenesis, clinical features and management of the disorders.

• 12. Disorders of Lipoprotein metabolism 20 min

  The physiology of metabolism of lipoproteins has been dealt with in this module followed by a discussion on the consequences of disturbance in this process giving the aetiology, pathogenesis, clinical features, investigations and management of each.

• 13. Disorders of Carbohydrate Metabolism 22 min

  The module talks about the disorders of metabolism of carbohydrates describing sequentially the consequences of disturbance at different levels of carbohydrate metabolism. The disorders have been classified on the basis of the fault that gives rise to them and each disorder has been thoroughly explained with regards to its aetiology, pathogenesis, clinical presentation, investigations and management protocol.

• 14. Introduction to Diabetes Mellitus 27 min

  Diabetes Mellitus is a disorder of carbohydrate metabolism but dealt with separately as being a lifestyle disorder, it requires careful study and demands extra emphasis while dealing with metabolic diseases. An overview of Diabetes Mellitus and its current status in the world has been talked about in this module.

• 15. Diabetes Mellitus: Aetiology & Pathogenesis 33 min

  This module gives an in depth analysis of the various aetiological factors that lead to Diabetes Mellitus and explains its pathogenesis in a simplified and easily comprehensible manner.

• 16. Diabetes Mellitus: Clinical Presentation 34 min

  This module describes Diabetes Mellitus as a lifestyle disorder explaining in detail, all the signs and symptoms that can help a physician to identify Diabetes Mellitus clinically.

• 17. Diabetes Mellitus: Practical Aspect 44 min

  This module talks about the practical aspect of Diabetes Mellitus that is the clinical examination of a patient who shows up either with pre-diagnosed Diabetes Mellitus or presents with signs and symptoms of Diabetes Mellitus or its complications.

• 18. Diabetes Mellitus: Management Strategies 52 min

  This module talks about the management strategies that are employed to deal with cases which present with one or more manifestations of Diabetes Mellitus. Each approach has been talked about in detail emphasizing the importance of dietetics, patient education and lifestyle management in the treatment of Diabetes Mellitus. A separate topic covering the modifications in management protocol for special cases like Diabetes Mellitus in pregnancy, childhood, surgical cases and acute medical emergencies has been added in the end.

• 19. Diabetes Mellitus: Complications & Their Treatment 51 min

  This module covers all complications of Diabetes Mellitus delving deep into their clinical features and management strategies.

• 20. Homeopathic Therapeutics in Diabetes Mellitus 32 min

  This module takes a dive into the homeopathic approach towards Diabetes Mellitus elaborating upon the various homeopathic medicines that help deal with the metabolic and lifestyle disorder conservatively and gently.

• 21. Clinical Assessment and Investigations in Metabolic Disorders 17 min

  This module explains the various approaches to clinical assessment of a case presenting with a metabolic Disorder. It also covers the major investigations that are required for accurately diagnosing a metabolic Disorder.

Importance: A. Metabolic Diseases, though rare may be encountered in a number of patients who appear before the physician with an apparently unrelated complaint. Thus, it is important to be well versed with metabolic diseases so as to be able to deal with them efficiently. B. Some metabolic diseases like Diabetes Mellitus have now become lifestyle disorders and are the major cause of blindness, amputations and death due to serious complications while other metabolic diseases like Porphyrias are nearly neglected as they are rare. Since both deserve judicious handling on part of the physician, it is important to be adept at it.

Beneficiaries: UG/PG Students

Course Benefit:

A. The course deals with the most important metabolic diseases covered in a way that the learner will be able to relate them with normal physiology and understand the deviation from normal which led to the development of the given disease.

B. Each module has been incorporated with the latest advancements and researches in the field of metabolic diseases to allow the learner to upgrade the conceptual knowledge as well as update himself/ herself with the latest facts and figures.