“The road to health is paved with good intestines.” This quote by Sherry A Rogers very well indicates the importance of healthy functioning of the Gastrointestinal and Hepatobiliary system. Most of our clinical practice is filled with such cases and thus it becomes essential for us to be well acquainted with the management of these conditions. Gastrointestinal and Hepatobiliary diseases affect the quality of life of a person and make them miserable to live with. This course aims to discuss the important homeopathic medicines, along with some rare homeopathic medicines indicated for the management of a number of Gastrointestinal and Hepatobiliary diseases.